I bought a DeSantis holster a few weeks ago for the M&P 45C and have been testing it as my EDC holster.
I've worn it both strong-side and cross-draw and found it to be very comfortable. The fit and retention is excellent. I find drawing from the strong-side very easy and from the cross-draw position only slightly more difficult, this issue could probably be resolved with more practice. Concealment is very good for an outside-the-waistband holster too with an untucked shirt. Another feature I like is that it is made in the USA and at $50 is quite a bargain in my opinion. The quality is very good and break-in didn't take long.